Recommendations for aerosolized antibiotics in ventilator-associated pneumonia and ventilator-associated tracheobronchitis: too little and too late?
نویسندگان
چکیده
منابع مشابه
Aerosolized antibiotics to treat ventilator-associated pneumonia.
PURPOSE OF REVIEW This review summarizes the recent data on antibiotic aerosolization to treat ventilator-associated pneumonia. RECENT FINDINGS Most studies on antibiotic aerosolization have been case reports or descriptive studies. The results of a recent randomized, placebo-controlled trial indicated that adjunctive use of nebulized antibiotic with intravenous antibiotics to treat purulent ...
متن کاملToo passive to prevent ventilator-associated pneumonia.
Ventilator-associated pneumonia (VAP) is a common complication of patients receiving invasive mechanical ventilation support. VAP continues to be associated with high morbidity, mortality, hospital cost ($10,000 to $25,000) and ICU stay.1 Depending on the definition used, the VAP rate ranges from 1.2 to 8.5 cases per 1,000 ventilators days.2 Prevention of complications and patient safety is cur...
متن کاملAerosolized antibiotics for ventilator-associated pneumonia: lessons from experimental studies.
The aim of this review is to perform a critical analysis of experimental studies on aerosolized antibiotics and draw lessons for clinical use in patients with ventilator-associated pneumonia. Ultrasonic or vibrating plate nebulizers should be preferred to jet nebulizers. During the nebulization period, specific ventilator settings aimed at decreasing flow turbulence should be used, and discoord...
متن کاملShould Aerosolized Antibiotics Be Used to Treat Ventilator-Associated Pneumonia?
In patients with ventilator-associated pneumonia, systemic use of antibiotics is the cornerstone of medical management. Supplemental use of aerosolized antibiotics with intravenous antibiotics in both experimental and clinical studies has been shown to have the following pharmacologic benefits: (1) aerosolized antibiotics reach the infected lung parenchyma without crossing the pulmonary alveola...
متن کاملTreatment of ventilator-associated pneumonia and ventilator-associated tracheobronchitis in the intensive care unit
OBJECTIVES To assess current practices of different healthcare providers for treating extensively drug-resistant (XDR) Acinetobacter baumannii (AB) infections in tertiary-care centers in Saudi Arabia. METHODS This cross-sectional study was performed in tertiary-care centers of Saudi Arabia between March and June 2014. A questionnaire consisting of 3 parts (respondent characteristics; case...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2017
ISSN: 1198-743X
DOI: 10.1016/j.cmi.2017.04.001